Non-thermal irreversible electroporation (NTIRE) for cancer therapy is a technique introduced by Davalos and Rubinsky1,2 in 2005. The emphasis was on the term, ‘non-thermal’, because membrane electroporation was used to kill cancer cells while protecting lethal heating effects to nearby critical tissue structures.
Possible reasons on how the use of a high number of electric pulses at low electric field strengths (0.5 – 1.0 kV/cm) can kill cancer cells, is discussed and NTIRE treatment of prostate, pancreas and liver, are summarised.
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